Disease-modifying antirheumatic drugs (DMARD) are active substances that are used alone or in combination to treat rheumatic conditions (e.g. rheumatoid arthritis). The drugs work directly on the inflammatory processes and, depending on the active substances, interrupt the transduction of certain signals. These substances are not recommended for people with immune deficiency or liver disease. The side effects vary depending on the active substances used, but in particular involve an increased risk of infection. The Swiss Atlas of Healthcare shows disease-modifying antirheumatic drugs dispensed by outpatient care providers.